eBooks
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The Complete Guide to Treating & Coping with Alzheimer's Disease
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Genetics of Alzheimer's Disease
Genes play a prominent role in Alzhimer’s disease, although the actual extent of their effect is still debated. It is evident that genes control and determine the color of eyes, hair and other traits in all living beings. However, genes do not function by themselves; they receive active help from other environmental characteristics. Genes depend on various physical and chemical features of their surroundings to give final shape to those traits.
Genes are present within the nucleus of every cell and build up a new protein with other molecules. The new protein should contain specific and appropriate DNA (deoxyribonucleic acid). Mutations in DNA could result in defective proteins, which might disable your body and cell functions. This may later lead to various irregularities and cause diseases, leading to death.
So, you might attribute Alzhimer’s disease to gene mutations. Most other gene disorders and diseases are due to irregularities in a single gene but Alzhimer’s disease may occur due to multiple gene disorders, not the work of any single gene. Multiple gene mutations, multiple chromosomes and defective genes of both parents could be part of the cause of Alzhimer’s disease.
Genes Affecting Alzheimer's Disease
Sporadic and Familial are two basic types of genes that are believed to cause Alzhimer’s disease.
Familial Alzhimer’s disease (FAD) refers to family inheritance of a gene causing this disease. One parent with such a defective gene could pass it to their offspring. All children have a fifty percent chance of acquiring Alzhimer’s disease in later years. This inheritance is called ‘autosomal dominant’. In such cases, mutations occur on chromosomes 1, 14, and 21. Familial Alzhimer’s disease affects people below sixty years of age.
Sporadic Alzheimer's Disease occurs more commonly than Familial Alzhimer’s disease (FAD). It affects persons above sixty years old. The Sporadic form is due to presence of the ApoE gene on chromosome 19. ApoE is present in many different forms; genes of apoE2, apoE3, or apoE4 occur frequently. You may inherit any one of them from each of your parents. Some people could even receive two of them. There is no conclusive proof to show which of these carry the higher risk of Alzhimer’s disease. Most affected patients carry two apoE4. Nevertheless, some people that are carrying two apoE4 do not contract Alzhimer’s disease at all.
How to Detect ApoE
Blood tests can help in determining the presence of apolipoprotein (apoE) in your genes. However, they cannot indicate whether you have Alzhimer’s or if you may or may not acquire Alzhimer’s disease later in life.
Currently, there is no accurate test to indicate whether apoE could cause the disease. ApoE testing may expose confidential information about different patients. Therefore, such testing is normally reserved for genuine Alzhimer’s disease patients only. You may take this test if you have many other positive indicators for Alzhimer’s disease.
Genetic counseling, before and after apoE testing, is helpful to patients and their family members.
It helps them to deal with this crisis in their lives while they suffer severe distress and depression with extensive emotional strain due to Alzhimer’s disease. However, apoE testing alone cannot confirm the risk of Alzhimer’s disease. A combination of many different factors like neurological, family history, and other irregularities in behavioral and functional abilities are needed for best diagnosis and plan for treatment and support. Only after that, can doctors discuss the existence of Alzhimer’s disease in any particular individual.
The above is an extract from the book The Complete Guide to Treating & Coping with Alzheimer's Disease.
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The Complete Guide to Treating & Coping with Alzheimer's Disease provides a comprehensive outline designed to help you explore the options for diagnosis and ongoing care if your loved one is afflicted. It is not meant to be a replacement for sound medical advice.
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